منابع مشابه
Sorting it out
The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alterna...
متن کاملDesmosomes sort it out
iochemical and kinetic studies have failed to provide a unified view on how the Arp2/3 complex nucleates actin filaments. Does the complex, which mediates actin filament nucleation and branch formation at the leading edge of motile cells, bind to the side of an older actin filament, or does it become incorporated into that filament? B Structural studies now add a new dimension to the discourse,...
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ژورنال
عنوان ژورنال: Nature Nanotechnology
سال: 2008
ISSN: 1748-3387,1748-3395
DOI: 10.1038/nnano.2008.338